In some degenerative diseases like osteoarthritis, a joint disease that occurs most frequently in the hands, hips, and knees, cells usually lack the amount of energy they need to function properly due to insufficient anabolism.
A team at Zhejiang University's School of Medicine has delivered photosynthetic proteins from spinach into mice cells, showing promising clinic potential to treat osteoarthritis.
Photosynthesis is the process by which plants get energy from sunlight. Both ATP and NADHP, which are energy storage and electron carrier/donor molecules, are produced in plants during photosynthesis.
Therefore, researchers wondered if it might be possible to deliver plant cells into mammalian cells to produce ATP and NADHP and activate the photosynthetic process when light is applied.
According to their paper published in the journal Nature, researchers created light-powered nanothylakoid units (NTUs) from plants to deliver ATP and NADPH to the joints of arthritic mice, successfully slowing the degeneration.
Based on the plant-derived natural photosynthetic system, this approach can improve cell anabolism by independently providing key energy and metabolic carriers, said the team.